The names sound similar, but a second-home buyer should compare them as distinct choices.
There is no universal winner between Myrtle Beach and North Myrtle Beach. The better choice depends on how you expect to use the property and what kind of ownership experience you want.
Central access to a large concentration of attractions, restaurants, airport convenience and a very broad condo/resort inventory.
A collection of established beach communities, Main Street/Ocean Drive culture, access toward Little River and a somewhat different north-end rhythm.
Drive the areas at the times you would actually use the property. Compare grocery runs, beach access, parking, traffic, noise, restaurants and the trip from your primary home or airport. Then compare the annual cost of the exact properties—not just asking prices.
Do not assume a property that rents well is automatically the best personal second home, or vice versa. Verify local and association rental rules, realistic management costs and the building's history before relying on projected income.